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A Phase II clinical trial involving 164 patients was recently showed that in patients with HER2-metastatic breast cancer, addition of indoximod, theIndoleamine 2,3-dioxygenase 1 (IDO1) pathway inhibitor, to taxane did not improve PFS compared with taxane alone (300)

However, if estrogen homeostasis is imbalanced by an increase in CYP1B1 and a decrease in COMT, a greater degree of genotoxic quinone formation from 4-OH-E 2 will occur

The next morning, the venous duplex was negative for DVT but did show a moderate size cyst in the medial aspect of the right calf area

At the same time, Im a little concerned about the message this type of self-experimentation may send to the wider audience