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In further support of this finding, the drug induced expression of several oxidative stress pathway proteins, including nuclear factor (erythroid-derived 2)-like 2 (NRF2), a master regulator of the antioxidant response and haem oxygenase 1 (HMOX1), encoded by the NRF2 target gene HMOX1 (Fig

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Howlett AC, Barth F, Bonner TI, Cabral G, Casellas P, Devane WA, et al

Recent observations highlighted the critical association with intestinal flora, as confirmed by the finding that metformin decreased the relative abundance of Bacteroides fragilis while increasing Akkermansia muciniphila and Bifidobacterium bifidum