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It is the main consumer of NAD + in aged tissues its activity increases significantly after age 40

Gut microbiota, its role in induction of Alzheimers disease pathology, and possible therapeutic interventions: special focus on anthocyanins

Proc.Natl.Acad.Sci.U.S A

In this unusual case, we present a patient with B12 deficiency who presents with severe macrocytic anemia, neutropenia, lymphocytosis, and a bone marrow morphology consistent with MDS