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Modern clinical research has shown that saffron supplementation (typically 2050mg per day) can improve visual acuity, retinal function, and contrast sensitivity in adults with AMD.58 These effects are attributed to compounds called crocin and crocetin, which may enhance retinal blood flow and protect photoreceptor cells from oxidative stress

10.1016/S2213-2600(20)30105-3 128 SousaA.ArajoP.AzevedoJ.CruzL.FernandesI.MateusN.et al (2016)

The two molecules work in a continuous redox loop

Microorganisms such as Enterobacterium , Enterococcus , Bifidobacterium , and Bacteroides , which are responsible for the production of short-chain fatty acids, were found to exhibit reduced abundance in blood and fecal samples from patients with CKD (50)