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The arrival of orforglipron represents a significant step toward making effective weight management accessible to a broader population

2.6 Meta-analysis Meta-analysis was performed using the R statistical program, R version 4.4.2 (The R Foundation for Statistical Computing, Wirtschaftsuniversitt Wien, Vienna, Austria) (Viechtbauer, 2010), employing a random-effect model via the metafor R package ( 3 Results 3.1 Study selection and characteristics The search strategy identified 2,183 potential articles: 1,299 from PubMed, 353 from Scopus, 527 from Embase, 4 from manual screening