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1 Introduction Brain is a major body organ that integrate several neurodegenerative diseases including Alzheimer disease (AD), Parkinson disease (PD), primary tauopathies, frontotemporal dementia (FTD), amyotrophic lateral sclerosis (ALS), synucleinopathies (such as Lewy body dementia [LBD] and multisystem atrophy [MSA]), polyglutamine-related diseases (Huntington disease (HD) and spinocerebellar ataxias [SCA]), prion disease (PrD), traumatic brain injury (TBI), chronic traumatic encephalopathy (CTE), spinal cord injury (SCI), and multiple sclerosis (MS) (Wilson et al., 2023)

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If you have additional questions, Jennifer Jose-Cappola, MD is here to answer your questions and get you started

As the condition worsens, symptoms become more constant daytime numbness, weakness, dropping objects, and eventually visible thinning (atrophy) of the muscles at the base of the thumb