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Key unresolved questionsincluding the exact temporal sequence and causal relationship between NTFs signaling dysfunction and mitochondrial impairment in human PD, the existence of an irreversible threshold beyond which intervention is ineffective, and the universal applicability of preclinical findings to sporadic PDmust be addressed through rigorous, human-relevant research

All patients received pemafibrate 0.2 mg (0.1 mg twice daily) for 24 weeks

Improves Metabolic Health: It helps improve glucose uptake and increase insulin sensitivity