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Corticosteroids, methotrexate, biologics like infliximab and adalimumab, they all work by dampening immune activity across the board

S.MobleyM.et al (2011)

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This stage of Lyme disease is so advanced that Lyme Literate Medical Doctors (LLMDs) often recommend intravenous antibiotics, administered through a peripherally inserted central catheter (PICC line)