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A literature search was conducted covering studies published between 2016 and 2025 using platforms including PubMed, Web of Science (WoS), Scopus, and Google Scholar

The predicted P eff value for D-NIe-Tyr-Ile-NH-(CH 2 ) 5 -CONH 2 (1.53) is intermediate between the predicted P eff values for enalapril (1.25) and piroxicam (2.14), two orally bioavailable drugs