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Alcohol depletes glutathione: Chronic alcohol consumption severely reduces hepatic glutathione through increased oxidative stress during ethanol metabolism [6][35]

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Such approaches, as tailored to specific stem cell types, age and disease context will likely expand opportunities for clinical translation

Drinking in the dark (DID) The standard DID ethanol drinking paradigm was used in mice to model human binge-like consumption behavior and was described in previous research [24]