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4.4 Preclinical Drug Development Disease Models The early discovery of SOD1 genetic ALS led to the development of SOD1 transgenic mouse models

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In a mouse study, the root extract of M

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In the thalamus, however, PDH activity was affected twice as much as TKT activity ( In cases of severe thiamine deficiency, however, a broad enzymatic deficiency encompassing all three mitochondrial TPP-dependent enzymes would be expected to result in symptoms similar to those of the genetic disorder dihydrolipoamide dehydrogenase (DLDD) deficiency (OMIM 246900)

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