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Tumor necrosis factor-: a potentially neurodestructive cytokine produced by glia in the human glaucomatous optic nerve head

In addition, it can both inhibit cystine uptake into cells via system x thereby promoting oxidative stress and, as it is a substrate inhibitor, promote L-glu release from cells via the same transporter, which can enhance excitotoxicity through activation of mGluR5 (Liu et al., 2009)