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doi: 10.1038/s41467-023-36882-6, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] Araz A

Dorsomorphin was administered at 4 M concentration from day 3

Necrosulfonamide (NSA), a MLKL inhibitor that blocks necroptosis by covalently binding to unique human Cys86 residue, was found to disrupt the functions of GSDMD-NT to oligomerize and form membrane pores, likely through alkylating Cys191/Cys192 39