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In a mouse model of colitis-associated colon cancer, HIF2 was shown to regulate Dmt1 activation, leading to an increment of intracellular iron levels and consequently contributing to increased cell proliferation and tumor growth [122]

Sixth, as in any repeated-measured crossover, practice effect was a limitation

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Within these comparatively autonomous mechanisms governing cell death, the introduction of Fer-1 substantially elevated cell survival rates, indicative of the effective suppression of OGD induced ferroptosis