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The duration of treatment may extend for several weeks, often continuing until patients reach their desired weight loss goals [11]

Green marks the knockout genes, while yellow highlights the representative strains with various knockout genes

Information sources Studies were identified by searching PubMed Medline, Ovid Medline, Embase, Scopus, Google Scholar, and the Cochrane Library to retrieve all available relevant articles

Lian Leng Low, [email protected] Specialty section: This article was submitted to Family Medicine and Primary Care, a section of the journal Frontiers in Medicine Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers