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doi:10.1016/0003-2697(79)90188-x

Certain metabolic changes are involved in cancer initiation, while others contribute to cancer progression [245]

In a year-long trial involving 50 HIV-infected patients who had been treated with antiretroviral drugs for an average of six years and had developed metabolic syndrome, metformin treatment significantly slowed the rate of coronary artery calcification compared to lifestyle modification