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When expressed in the CHO cell line, the hKOR was demonstrated to undergo a time- and concentration-dependent uncoupling from G proteins but with a moderate impact on the inhibition of ACase (a two-fold increase of the EC 50 value of the KOR agonist U50488) (Zhu et al., 1998)

The peptide degradation research overview covers the compound integrity considerations, and the peptide purity and COA interpretation guide covers content verification