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While antioxidant response enzymes are well-characterized transcriptional targets of NRF2, it is recently becoming clear that NRF2 also supports cellular detoxification through metabolic rewiring to support the antioxidant systems

N Engl J Med 351:7880 May M, Mocroft A, Guest J et al (2013) Contribution of AIDS and non-AIDS deaths to lower life expectancy of ART-treated HIV + individuals compared with the general population

Since the ER, unlike other organelles, is the primary site for the translation of secretory and membrane proteins, we also analyzed RNA content

Therefore, improving lymphopenia and reducing inflammation may represent effective therapeutic strategies for patients with COVID-19