It is important to note that few studies have examined omics biomarkers in relationship to existing clinical criteria, such as coma or a constellation of clinical and laboratory findings (i.e., Kings College Criteria) currently in use by clinical practitioners as a prognostic indicator
Will Cole: Intuitive Eating, Intermittent Fasting, Inflammation Benefit #1: Microbiome Diversity Intermittent fasting is great for human gut microbiome diversity
IGF-1 is a highly anabolic peptide hormone responsible for: Muscle cell proliferation and repair Tendon and ligament regeneration Bone growth Glucose uptake in muscle cells Increased satellite cell activation Oral administration of MK-677 raised serum IGF-1 levels by over 60% in healthy adults without altering cortisol, insulin, or gonadotropin concentrations. Chapman et al., Clinical Pharmacology & Therapeutics This rise in IGF-1 is what leads to muscle growth, improved recovery, and increased physical resilience over time
Cargo selection in these pathways is often achieved via the binding of an autophagy receptor that harbors a consensus LC3-interacting region (LIR), a stretch of 4 amino acids to facilitate its direct binding to the LDS (LIR-docking site) of LC3 orthologs