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10.1038/s41392-024-01839-8 123 ZorovD

Skin-whitening cosmetics are high in demand throughout Asia [1, 2]

( 2+ and ROS, and mitigating peroxidative damage ( While current studies have delineated the core roles of ferroptosis (via the System Xc GSHGPX4 axis, iron overload, lipid peroxidation, and mitochondrial dysfunction) and identified antioxidant networks (Nrf2/Sirtuins/FTH1) as therapeutic targets in DN, several critical research gaps persist that hinder a comprehensive understanding of ferroptosis-driven DN progression and translational application