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The view that IL6 is involved in sleep regulation is further supported by the observation that exogenous administration of IL6 in humans caused profound somnolence and fatigue (143), while in another study, its administration was associated with an increase of SWS in the second half of the night, suggesting a direct action of IL6 on central nervous system sleep mechanisms (144)

4 Flavonoids therapeutic applications in inflammatory diseases Flavonoids have been demonstrated to exert regulatory effects on immune cells and inflammatory factors