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It declines with age, and lower NAD+ is associated with slower metabolism and the changes we lump together as getting older. NNMT, meanwhile, consumes the raw materials your body uses to make NAD+ and in fat tissue, NNMT is often overexpressed, which can drag NAD+ down right where you least want a sluggish metabolism

This selective mechanism produces metabolic safety benefits that may make AOD-9604 appropriate for individuals who cannot tolerate or have contraindications to conventional growth hormone therapy

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[cited 2022 Apr 7]