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In addition, our study contributes to the limited available data on G6PD enzyme activity in both Madagascar and Ethiopia

Protein therapeutic molecules, including antibodies (Schmitt and Greten, 2021), metabolism-blocking proteins (Liu et al., 2017), enzymes (Yu et al., 2024), and apoptosis-inducing agents (Hu and Kavanagh, 2003) have also been successfully combined with engineered bacteria for targeted therapy of tumors (Table 1)

The key mismatch driver is the constitutive hyperactivation of the nuclear factor erythroid 2-related factor 2 (Nrf2) antioxidant pathway in tumor cells

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