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The development of hyperkalemia associated with potassium-sparing diuretics is accentuated in the presence of renal impairment (see CONTRAINDICATIONS)

The copper component of the complex serves as an essential cofactor for lysyl oxidase, an enzyme that catalyzes the cross-linking of tropoelastin molecules into functional elastic fibers with the mechanical properties required for tissue resilience

Reduces adiposity, sustains muscle function, and optimizes glucose metabolism

J Am Chem Soc 144:72837294 Shima H, Tsurita G, Wada S, Hirohashi Y, Yasui H, Hayashi H, Miyakoshi T, Watanabe K, Murai A et al (2019) Randomized phase II trial of survivin 2B peptide vaccination for patients with HLA-A24-positive pancreatic adenocarcinoma