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Published studies in rodents report that oral acetaminophen treatment of male animals at doses that are 1.2 times the MHDD and greater (based on a body surface comparison) result in decreased testicular weights, reduced spermatogenesis, reduced fertility, and reduced implantation sites in females given the same doses

For xenograft studies, animals were allocated into groups ensuring the mean, median and standard error of tumor size was similar across all groups

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