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Meanwhile, at 100 M, curcumin induced substantial cytotoxic effect to neuron cells as more than 4 fold reduction in cell viability was observed after 24 h treatment

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Moreover, their large molecular size limits bloodbrain barrier penetration, which can be either an advantage or a challenge depending on the therapeutic context 164

Furthermore, Lachnospiraceae, Lactonifactor , Alistipes and Subdoligranulum were more abundant in HT patients with normal thyroid function while Phascolarctobacterium was more abundant in patients with hypothyroidism