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Description

and (ii) off-target resistance caused by the activation of bypass signal transduction resulting from the amplification of the ERBB family of receptor tyrosine kinase genes, BRAF amplification, KRAS amplification, and KRAS mutations [148]

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Researchers believe combining them could target four metabolic pathways, but no formal data confirms its safety or effectiveness

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Receptor desensitization: Continuous use beyond 68 weeks may lead to diminished response

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