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Mutant SOD1 proteins can form toxic aggregates and lose their enzymatic activity, leading to increased oxidative stress [168]

[DOI] [PMC free article] [PubMed] [Google Scholar] Whitworth AJ, Theodore DA, Greene JC, Benes H, Wes PD, Pallanck LJ

2.5 Immune dysfunction In UC, intestinal inflammation is driven by sustained dysregulation of both innate and adaptive immunity, which together propagate and amplify mucosal injury (Yue et al., 2024)