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Description

Preclinical studies found that treating neuronal, nematode, or rodent AD models with NR resulted in induction of a mitochondrial stress response, including UPR mt and mitophagy, reduced proteotoxic stress, and decreased A accumulation 243

These two papers established the preclinical foundation for everything that followed

PMID: 33645410 | doi:10.1080/01443615.2020.1854696 Dimet-Wiley A et al

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