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Interactions between gut bacteria and intestinal epithelial surfaces of host cells have been identified to activate a variety of signaling pathways that regulate host pathophysiological processes such as energy metabolism, local and systemic inflammation, and oxidative stress ( SCFAs can also cross the gut barrier and attach to receptors on other cell types, such as hepatocytes, adipocytes, and muscle cells, activating the AMPK pathway and improving glucose and lipid metabolism

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