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For estimated changes for selected procedures, we refer readers to Table 168

Generally, after 812 weeks of continuous use, a 4-week washout period is required to avoid tolerance from long-term continuous use

In detail, these authors retrospectively evaluated the electronic health record database of PsO patients to assess the risk of incident inflammatory arthritis after initiation of biological therapies over a mean time span of 2.4 years, finding the risk of developing inflammatory arthritis to be significantly lower in patients under treatment with IL12/23 inhibitors (adjusted HR 0.58, 95% CI 0.430.76) or IL-23 inhibitors (0.41, 0.170.95) compared to patients treated with TNF inhibitors, while no significant difference was observed between IL-17 inhibitors (0.86, 0.541.38) and TNF inhibitors