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Published rodent protocols typically use subcutaneous or intraperitoneal injection in saline vehicle, dosed in pulsed courses (for example 1 g/kg daily for 10 days, repeated quarterly)

HDFA treatment targets the blockage in the transportation of folate into the brain through the folate receptor alpha caused by blocking or binding autoantibodies (Frye et al., Overall, this study provides some insight to the potential benefits of safe and well-tolerated therapies that target specific metabolism abnormalities associated with ASD