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HFD high-fat diet mice in the vehicle cohort received three subcutaneous (SC) saline (1 ml/kg) injections/day ( 0930, 1330, 1730 h) and mice in the treatment cohort received three SC injections of the NNMT inhibitor 5-amino-1MQ at a dose of 20 mg/kg/injection for a total dose of 34 mg/kg/day of the parent compound (calculated according to free weight) for 11 days

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Retatrutide and 5-Amino-1MQ: Evidence, Safety, and UK Regulatory Status Retatrutide and 5-Amino-1MQ are two compounds generating considerable interest in metabolic health and weight management circles, yet neither holds a marketing authorisation in the UK

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