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doi: 10.1186/s40169-014-0033-2 87 RuysseveldtEMartensKSteelantB

Adv Med Sci (2015) 60:17985

Brequinar, an inhibitor of dihydroorotate dehydrogenase (DHODH) in the de novo pyrimidine biosynthesis pathway, was found to suppress tumor growth in xenograft models of SCLC ( Gln-Fructose-6-Phosphate Aminotransferase Gln-fructose-6-phosphate aminotransferase (GFAT) is the rate-limiting enzyme of the hexosamine biosynthetic pathway (HBP), and it will transfer amide nitrogen from Gln to fructose-6-phosphate in the first and subsequently generate amine-6-glucose phosphate (GlcN-6-P)

Examples include, but are not limited to, triacetin, triethyl citrate, ethyl oleate, ethyl octanoate, dimethylacetamide, N-methylpyrrolidone, N-hydroxyethylpyrrolidone, polyvinylpyrrolidone, hydroxypropylmethylcellulose, hydroxypropylcyclodextrin, ethanol, polyethylene glycol 200-