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The chalcone class is another natural compound reported to inhibit GST activity (Figure 4B)

The majority of studies also lacked statistical power to adjust for appropriate covariates or rule out false negative findings

Hajimohammadi, A

Kee et al., 2023) and meta-analyses reinforces that genetic differences in drug-metabolizing enzymes directly influence plasma concentrations and clinical outcomes, with poor metabolizers tending toward higher exposure and potential toxicity, and ultrarapid metabolizers often demonstrating underexposure and poor therapeutic response