what is a melanotic macule

what is a melanotic macule Labial (brown spot on lip) (Stony Brook Case 1) dermatology dermatopathology Melanotic macule. Benign. Dark spot

Name: what is a melanotic macule Labial (brown spot on lip) (Stony Brook Case 1) dermatology dermatopathology Melanotic macule. Benign. Dark spot
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Melanotic macule. Benign. Dark spot on labia (or lip). Analogous to lentigo simplex. Hyperpigmented basal keratinocytes & dermal melanophages. Slight in single basal melanocytes; NO nests. More info like this in Freckle on Lip: Meaning, Causes and Is It Dangerous? (Labial Melanotic Macule) Oral pathology: Noting a pigmented macule that often presents a diagnostic dilemma Registered Dental Hygienists Congenital Melanotic Macule of the Tongue: Report of Two Cases and Literature Review Head and Neck Pathology Springer Nature Link

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This condition, in turn, can promote the intestinal absorption and hepatic secretion of cholesterol with effect on rapid cholesterol nucleation and crystallization

Since there is limited knowledge about pre-MM lesions and a lack of corresponding molecular pathological biomarkers, early diagnosis, as well as early intervention becomes extremely challenging, leading to the short life expectancy in MM patients