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New Episode News and Public Affairs Top journalists deliver compelling original analysis of the hour's headlines

doi: 10.1146/annurev-micro-032521-015858 61 ChowdharyA.MeisJ

Upregulation of iron transport proteins such as transferrin (Tf), transferrin receptor (TfR), and divalent metal transporter 1 (DMT1) enhances cellular iron uptake, while loss or dysfunction of ferroportin 1 (FPN1) hampers iron efflux, leading to intracellular iron overload and oxidative damage