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alleviate neuropathic symptoms, like allodynia and hyperalgesia

Calabrese and his colleagues have also made significant efforts to refine the definition and classification of hormesis: an adaptive response of biological systems to low-intensity stressors, characterized by a biphasic dose-response curve with a stimulatory zone (typically 0.1-10 times the No-Observed-Adverse-Effect Level, NOAEL) and an inhibitory zone 7

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These phases have been seen and functionally dissected in several PFF models and neuronal tracing experiments