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Synbiotic strategies pairing Akkermansia with culturally adaptable prebiotics (inulin-rich local staples) may democratize access, ensuring microbiome interventions align with diverse dietary practices

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Finally, GIP assessment, a controversial test still awaiting further validation, can be performed on stool samples and may be useful for monitoring the adherence to a GFD [48]

534 Mechanistically, metformin enhances autophagy, promoting clearance of immune complexes and dysfunctional organelles, thereby reducing inflammatory burden