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The tissues collected from each group were collected in 0.01 M PBS with protease inhibitors [2 g/mL aprotinin, leupeptin, pepstatin A, and 120 g/mL phenylmethanesulfonyl fluoride (PMSF)] and homogenized (Polytron RT MR3100) at 3 10-s intervals

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit

the mouse study used dosing three times daily

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