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Discordance between ex vivo potency and in vivo PK/PD has many potential causes, one of which, in the case of schistosomicidal agents, is the involvement of the host immune response

Because peroxides can decompose to form highly reactive radicals, the GPX enzymes play a critical role in protecting the cell from free radical damage, particularly lipid peroxidation

The mean age at the onset of symptoms is generally in the third or fourth decade of life

Moreover, elevated DNA methylation could be exploited by EBV-infected cells for transformation through viral DNA methylation, preventing their replication and favoring the establishment of different types of latency that allow evasion of the immune system (226)