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While all treated mice were desensitized and protected during subsequent challenges, high-dose treatment caused severe systemic reactions

H.et al

in Italy assessed the efficacy of a hydrolyzed collagen supplement (5 g per day) to improve skin moisturization, elasticity, and the appearance of wrinkles in 52 women (4060 years of age), where 26 women received the supplement and 26 women were given a placebo for a total of 56 days [41]