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Batch effect correction was conducted using the Harmony R (v0.1.0) package 53

Thus, trained HSPCs enhance the bodys resistance to infection, and the mature immune cells generated by their differentiation have a more robust response strength to secondary infections, ultimately improving the bodys defense against pathogenic microorganisms

However, based on the complexity of the BBB and the diversity of the molecules involved, combination therapies and optimal drug carriers, such as nanocarriers, are likely to be required for the efficacious treatment of BCBM, although further clinical trials will obviously be needed

Chem Biol Interact 111112 : 199211