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You mentioned before chemo brain, and I think it's important that we think that blood-brain barrier disruption occurs among many neurological conditions, and it's an early event associated with early disease onset and worse prognosis in multiple sclerosis, Alzheimer's disease, traumatic injuries

Dihexa is a first-in-class compound that is orally active, penetrates the blood-brain barrier, and facilitates memory consolidation and retrieval

Liu et al., 2005

To elucidate the essential role of Dj1 in atherogenesis, we generated global double knockout Dj1 / Apoe / mice by crossing Dj1 / mice with Apoe / mice