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phosphorylated GSK3 (Ser9) level was significantly downregulated in Prx II-knockdown HaCaT cells after H 2 O 2 treatment, accompanied by a marked decrease in the phosphorylation levels of its upstream kinase PI3K and AKT (Fig

In intestinal epithelial cells, this enhanced contractile tension induces centripetal contraction of the perijunctional actomyosin ring, leading to internalization and reorganization of junctional proteins, including claudins, occludin, ZO-1, and adherens junction components, resulting in reversible TJ opening and increased paracellular permeability

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The GABA(B) receptor blockers increase active brain states such as when were awake or in REM sleep (dreaming stage) [46]