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Additionally, miR-21 is overexpressed in activated B cells and can be induced by IL-4 alone or in combination with CD40 or IgM co-stimulation with lipopolysaccharide, suggesting that miR-21 may contribute to maintaining excessive activation of B cells and promoting lymphomagenesis [262]

it is generally represented by the formula: Ri(CO)NR 2 R3, where either or both R 2 and R3 may be hydrogen