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heterocycle or heterocyclic ring moiety may be unsubstituted or substituted by one or more groups selected from halogen, haloalkyl, hydroxy, alkoxy, carbonyl, alkylamido, nitro, amino, dialkylamino, carboxy, thio or thioalkyl

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Compounds were initially tested for NNMT inhibition activity at 100 M or 1 mM concentration (compounds with no activity at 100 uM were tested at 1 mM concentration)