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Although most studies in patients receiving Bu based conditioning regimens show positive significant contributions of these haplotypes with Bu pharmacokinetics (PK), adverse events, or disease risk 22,23,24,25 , there are still several other studies that have reported negative findings, casting doubt on the role of the promoter SNPs

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Dissemination of these clones could partly be due to carriers, where it is estimated for every VRE patient, there are 210 fold more transient carriers [101]

Sertoli cells exhibited a predominant presence of DEGs that were involved in various biological processes, including oxidation by cytochrome P450, amino acid metabolism, acetylcholine synthesis, serotonin transporter activity, biosynthesis and regeneration of tetrahydrobiopterin, catabolism of phenylalanine, the p53 signaling pathway, and base excision repair