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In patients with primary insomnia, a 14-day trial comparing trazodone, zolpidem, and placebo revealed that trazodone improved sleep latency and duration (measured by a questionnaire) compared to placebo, but zolpidem had a greater effect (Silber, 2005)

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Two-way ANOVA revealed a significant interactive effect of LC and TMX on CAT ( F = 8.751

Furthermore, a prospective study involving 761 CRC cases revealed that TMAO and its precursors are positively associated with the risk of distal colon cancer, while no significant association was found with the overall risk of rectal cancer (Byrd et al., 2024)