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MITOCHONDRIAL ROS GENERATION AND DEFENSE Reactive oxygen species can be generated in several intracellular sites, including cytosol, peroxisomes, plasma membrane, and ER

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Although the mechanisms remain unclear, the ability of KD to enhance mitochondrial function and increase energy production may contribute to these effects, as HD is also characterized by impaired mitochondrial activity and reduced cellular bioenergetic capacity [95]

[16] However, a consistent association was found between the mitochondrial ancestral K* and J* haplotypes and MS in caucasians